Best and worst most extreme departures long running series have taken?

[LegitHyperbole]

Also another best and worst. MGS5, it's best cause it's the best action stealth game ever created by far and none will come close to it anytime soon and by coincidence the best 80's action, Rambo simulator and one of the few that is actually good. The worst cause it fails at being an MGS game story wise, it's clearly an unfinished game and it actually hurts MGS lore. Kojima clearly wanted to come full circle and have you, as big boss, fight Solid Snake at the end of the game and make a perfect loop but Konami didn't want him to close it out forever so we got this, unfinished half assed, brilliantly crafted utter mess, wonderfully designed masterpiece of a game.