Resident Evil 5 . But i think Uncharted 2 will take the place.

Current GOTY: Killzone 2

Will be GOTY: Uncharted 2

Final Runner Ups: COD: Modern Warfare 2, Killzone 2, Batman Arkham Asylum

infamous baby!And when U2 is out Drake will take it from Cole's hands!
Come ppl RE5???That was my BiggestDissapointmentOfYear for sure!Not GOTY.Come on

Halo ODST or Resident Evil 5.

Halo Wars

It's close between Batman: AA and Killzone 2. If it were just single player I'd go Batman, but I guess I'd give it to K2 for the whole package.

Current Batman: AA
Reality: Uncharted 2

Killzone 2

Batman AA at the moment, Killzone 2 is a close runner up.

But its really doesn't matter, Uncharted 2 will destroy them both anyway.

quick update ^

Uncharted 2 leading the way for predicted Game of the Year with 15 votes.

Killzone 2 barely edging out Batman Arkham Asylum in votes for current Game of the Year. With runner up votes included its 15-14.
Batman was such a good game. Its so close to being my game of the year and thats saying a lot because its single player. If RE5 was only single player I would give the nod to batman so the better story, atmosphere and voice acting. But I played RE5 co-op with one of my best friends and it was my most enjoyable co-op experience to date. The full co-op campaign propelled that game to AAA for me.