Some of these woul be more suited for TGS rather than E3, but whatever.
Sony
Twisted Metal official announcement (won't happen, confirmed by Jaffe)
All PSP games become downloadable, and playable on PS3
Return of The Leged of Dragoon
Announcement of Metal Gear Solid 5 and/or Metal Gear I & II remakes
Tales of Destiny 1&2 PS2 and Tales of Rebirth announced for Western release
Microsoft
Half-Life 2: Episode 3 dated for 2009
Portal 2 firt look/trailer
Anything from Mistwalker
Nintendo
Golden Sun 3
In-house developed Wario Land 5
Zelda Wii
VC for DSi
Success and Atlus announce "The Dark Spire 2" with a simultanions Western and Japanese release
Dragon Quest IX & X are being localized and marketed by Nintendo; 2009 release date for DQIX
Dragon Quest VII DS, and Dragon Quest I-III enhanced ports onto WiiWare
Final Fantasy VI on virtual console in 2009
Other
Next SMT game (I don't care what platform)
Square Enix decides to drop their spinoff strategy for main series Final Fantasy games