@Berstuck, it could be huge. Just think, ten or twenty years from now there may be whole groups of musicians who learned to play from video games. I have a couple real guitars, I never learned more than a few cords and screwed around with them. This kind of marriage between video game and music is exactly what I needed to motivate me to learn to really play. And hey if I get some gamerscore in the process, well, not a bad deal :)
Still unclear on if you can use your existing electric guitars or if you have to buy a special Rock Band brand guitar to do it with though... I would hope for an adapter or something.