Cole Train getting the Mic and start to yell / rap = classic

 You fight like a dairy farmer

Even at his most powerless, man's existence is never without meaning.
- Suikoden's Intro

"Now we can fight to our hearts' content."
"Too bad I have to fight with you."
- Viktor and Flik escaping from Gregminster Palace.

My most memorable is definitely "Hey, listen" from Navi in OoT.

I'd also say that The Simpsons game has lots of memorable quotes, but they're all from the series, so they might not really count.

Dante: "First I whip it out, then I thrust it, with great force. Every angle, it penetrates. Until, with great strength, I ram it in. In the end, we're all satisfied."

Dante : You can hide that body... but the smell... oohhh theres nooo covering it up.

Nero to Agnus:
"That's a bit harsh isn't it. Killing me because of the way i t-t-talk."

Nero: And now....you....DIE!!!
Nero : Go blow yourself.

Devil may cry 4

There's nothing like the sound of hundreds of voices screaming in unison.
- Kefka

This http://www.youtube.com/watch?v=vugT4g4Twtk

or from bully

"Your Mama"








Off topic .... i lol'd with this http://www.youtube.com/watch?v=lfh-ZZPZPCA

hmm ima have to say.. Do a Barrel Roll lol

That is one of my friend's ringtones when he gets a text message.   I want to punch him in the face whenever he gets a text message.

lol, you a fan of Navi's??

Actually, I am... but he gets a lot of texts.  Even my tolerance isn't that high.