RYNOCIRATOR (RY3NO V5) Also from Ratchet and Clank

Blades of Chaos in God of War

Spartan Laser in Halo 3. It may be pretty much useless, but it's still awesome.

Groovitron has to really come up there, as does the Ryno, both from Ratchet Tools of Destruction

If you count it, your wrecked car in Burnout Paradise showtime

This may be a surprise pick, but the Wes 44 in Uncharted. The pistols in that game are genuinely useful, and that pistol is plain awesome

Kimber classic custom in .460 Rowland
Remington 700vs in .308
Mossberg 590 12ga with choke tubes
MAK-90

Gamewise has to go to the gravity gun

Dispersion Gun - Timesplitters Future Perfect
Dragunov - Metal Gear Solid 3
Agni & Rudra, Cerberus - Devil May Cry 3
Blades of Chaos - God of War
Devil's Arms - Tales of Symphonia

AK-47

The Blade Arm from Megaman Legends 2.
Or the Ultimate Armor Nova Strike from Megaman X4, 5, & 6.
And the Rift Ripper, RYNO II, & Liquid Nitrogen Gun from R&C series.

WAIT, and the Soul Calibur and Soul Blades Swords that Siegfried and Nightmare wield.
No, there's more. The Last Resort from Dark Cloud 2.
And the Warp Ball from CTR.

There's probably more. Can't think right now. "Weapon" is such a general term.

AKS-74U. The best of the AK class of rifles.

This. My roomate and I have been playing Super C a lot lately and I go into BAMF mode with the Spread Gun.

Best Weapon Ever - Nuclear Bomb

- Killed 70,000 initially in Hiroshima, and by 1950 had killed up to 200,000 due to cancer, radiation, burns, and lack of medical resources.

- Killed 40,000-75,000 initally in Nagasaki, and an estimated 80,000 by the end of 1945.


This forced Japan to surrender, and the US won the war against Japan


http://en.wikipedia.org/wiki/Atomic_bombings_of_Hiroshima_and_Nagasaki#Post-attack_casualties

yeah i sourced wikipedia, deal with it

Notable mention to Atma Weapon + Illumina + Offering + Genji Glove on Final Fantasy VI.