Second hint for the one remaining game.

#45

-Fighting against Blight

-Luca

#44 

-A thousand years can weigh heavy on a person  Lost Odyssey

#43

-Brush  Okami

#42

-The end is in sight from the start  The Legend of Zelda: Breath of the Wild

#41

-Grass -> Desert -> Water -> Giant -> Sky -> Ice -> Pipe -> Dark  Super Mario Bros. 3

Maybe 45 is Morrowind, is my first guess.

Easy hint 4s for the 2 remaining games.

50. This action JRPG was first on the PsP, and adapted to modern consoles much later.
Unlike another handheld entry before it and even after it, the battle system is similar to the more famous entries.
You take on enemies as 3 different characters with an overarching story. These characters were named after the elements in latin.
The initials of this series is KH.

49. This JRPG was actually made possible by sony first party during the Ps2 era.
The game features pig latin as the main affliction to overcome.
sometimes the titular protagonist/antagonist will help you with enemies with powerful magic or hitting them with his face.
The title of this game when completely translated to English would simply be Shadow King Shadow King.

No, I've never actually played Morrowind. 

50) Ahh it's Birth by Sleep? Tried to play it earlier this year but didn't get far

Well how about FFXVI, I know you played that this year and there is blight in that game too.

Hint #50: Mario stepped down as referee for this title but the new guy clearly doesn't know the rules of the sport since a lot of your opponents blatantly cheat.

Hint #49: A lot of party members sacrifice themselves along to the way but most end up just fine.

Hint #48: Worst first day EVER! AGAIN!

Hint #47: Vampires, creepy dolls, monstrous babies, fish man, lycans and Magneto

Hint #46: Recently remaster (too recently to include in this edition) this rogue-like has survivors of a shuttle crash face impossible odds to to get off a very hostile planet.

Gonna go ahead and post my second batch:

45) Cyborg Ninja Origins

44) I rewatched nearly all the films about this character this year. The first three are still the best

43) These last two years have brought two new ways experience this game's story

42) My death count: 6457

41) You can throw eggs at the enemies, though it's a questionable strategy