Megiddo said:
Do you know what would be a lot more help for those with chronic Hepatitis C infections? If the pills didn't cost $500 to $1000 each.
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It was a $10B+ investment along with the fact that there are now less suitable patients than before because less people get infected with Hepatitis C since a cure is available so it is reasonable why Gilead would charge the drug relatively high prices but when you compare the other available alternative which is paying half a million dollars for a liver transplant with the possibility of a transplant rejection, Sovaldi seemed like a steal by comparison ...
I'm surprised why Gilead didn't charge as much as 400K for the entire treatment cause it still would've been a pretty good deal since it was undercutting the next best thing by about 100K which was a transplant operation and the other upside was not having to deal with a graft vs host disease ...
Besides, pricing was only a temporary setback for a huge leap forward for the rest of humanity ...
Megiddo said:
Also, your lack of awareness regarding Gilead Sciences is hilariously in plain view. For you see, Gilead Sciences had nothing to do with the creation of Sovaldi. No, that drug was researched and created by Pharmasset. The only thing Gilead do was buy out Pharmasset. That's all Gilead ever does. They buy out other companies who already did the research and then gouge prices so high despite them never spending a dollar on the actual R&D.
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I am aware that drug was originally developed at Pharmasset however, with that being said it does not explain the gap in the length between the acquisition (2011) and FDA approval (2013) for the drug candidate. The drug candidate at the time was still very much in development and I imagine it was sometime during phase 2 clinical trials that the acquisition took place but Gilead still had to takeover operations to get the drug to market ...
The statement "they buy out other companies who already did the research and then gouge prices so high despite them never spending a dollar on the actual R&D" is ultimately not true and in the end is just empty. Now what's hilariously in plain view is you corroborating these baseless claims ...
What makes your statement even more dubious was Gilead's introduction of Harvoni (extra funds to develop) which was an even more potent Hepatits C cure than Sovaldi was ...
@Bold Now that's a patently false statement if I've ever seen one ...
If you actually read the article you would know that Pharmasset had an IPO of $45M in 2007 which likely meant that whatever government contributions were towards Dr. Schinazi's initial findings it never exceeded that amount. By comparison Gilead had purchased Pharmasset for $10B+ so public funding contributions obviously paled in comparison to what Gilead had to pour in ...
Just because the NIH gave Dr. Schinazi some funds to create some compounds in a university laboratory does not mean that drug development was largely finished. It's easy to create several dozen candidates but it's hard to show that any of them are safe and effective for human consumption when they undergo live clinical trials ...
Megiddo said:
So I do thank you for not doing hardly any research (you actually thought that Gilead brought about Sovaldi) and for highlighting yet another reason big pharma is terrible. They have other people do the research, usually with funding from the government, and then buy up those people and market the drug for pure profit.
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Funding from the government is not very useful ...
NIH studies =/= Pharma studies
What the NIH looks at is often very generalized biomedical research. What big pharma wants to know is if it's targetable or not to be able to make a drug candidate that can trigger an effective response ... (much of biology research is just crap to pharma companies and maybe it's less so for biochemistry research)
The way public funding is setup is not that useful now and big pharma likely wouldn't miss much if the NIH was abolished since they can likely absorb whatever minuscule costs they truly covered. Much of the pre-clinical study is covered by biotech startups rather than universities which already diminishes their role to drug development and then when they get to phase 2 or 3 clinical trials they either go big by being acquired by a larger pharma corporation to further their funds or some turn out to become pharma companies by themselves ...
It's really funny how a bunch of armchair experts like yourself keep insisting solutions towards applied scientists (at which I'm pursuing a specialty in) who probably knows far better than you do at their own game but since you're so eager to thwart big pharma yourself maybe you should take up the mantle of enrolling in your local or state school's doctor of pharmacology program so that you can be the genius visionary that can bring new drugs a breakneck pace for pennies to put them to shame if you actually can ...
Last edited by fatslob-:O - on 08 October 2018