In some ways, yes. Also, I think it may be worth pointing out the Portal story doesn't conclude on a note of enmity between Chell and Gladdos.
I mean, in some ways, how? I can't think of a single time in the Portal games where the protagonist being a woman had any sort of effect on the story. If all that's needed for feminism is a female protagonist then I guess I could see your point. I would think there'd have to be some sort of substance behind it though. I'd say there's a heck of a lot of enmity at the end of Portal 2. The ending theme is literally "Want You Gone".