Fair points, there are a lot of unknowns its true.

But we have no idea how far from the Milky Way the reapers are. They could be some enormous distance, or quite close. It could be that the larger ones can travel enormously fast, but have to wait up for the smaller ones.

Hopefully we'll all know by the end of the year!

I hope that too!

Even if they sit/hibernate 60,000 light years away (half the diameter of the Milky Way), they would still be 2.44 million light years from Andromeda. It might make sense they'd visit one of the smaller clusters orbiting the Milky Way as those might be reachable. But they are without age and as AI, have a certain 'timeless' aspect to them (I mentioned before they still need energy). Humans making the journey? I'm not so sure about. They should just look for planet in dwarf galaxies around Milky Way, Reapers might not look there.

Mass Effect: Large Magellanic Cloud does have a certain ring to it.

I'm excited for it, but I'm hoping that both Bioware and Bethesda will soon rediscover their roots and add more actual RPG to their RPG's, Mass Effect 2 and (especially) 3 were taking a turn for the simpler road, much too simple, it was more or less third person shooting with some RPG elements (much the same happened with Dragon Age).
The shooter elements in the first one had issues, but it was more of a thoroughbred RPG; as the sequels fixed the shooting parts, they shed the RPG depth more and more and they never further improved or explored the moral system, sticking with the black & white style of paragon vs renegade, which is less than a franchise with such behemoth ambition and such a rich gallery of characters deserves.

I'm hoping for something grand with Andromeda, we certainly know they posses the talent for creating amazing titles.

Mass Effect 2 sold better than Mass Effect, and ME 3 sold better than 2, so I doubt they'll go back .

I fear we'll have to wait for Cyberpunk 2077 for a true shooter & RPG, and we'll have to see if CD Projekt manages it.

I definitely agree with the math of the situation.

But there are so many story devices to get around it.

Take the Normandy. It is a revolutionary and unique ship, at the bleeding edge of human/turian technology because of its stealth features.

The Illusive Man developed Quantum Entanglement to send video chat instantaneously across the galaxy.

Bioware could quite easily say that an experimental, very fast ship was developed and sent to Andromeda. Even then, with talk of it taking place a 1000 years on, it could still be plausible within the game's universe that it was a hibernation or generational ship.

I'm excited, I'm excited to see how humans actually manges to get to Andromeda, travelling around a whole galaxy is one thing but actually getting to another completely different galaxy is on a completely different level.

http://www.forbes.com/sites/insertcoin/2016/02/16/lead-writer-of-mass-effect-andromeda-leaves-bioware-to-work-on-destiny/#5915478018cb

The lead writer of Mass Effect Andromeda unfortunently left. I won't be posting it on the the OP, though I did want to leave this here as a reference. 

What other games has that writer been on? Was he responsible for previous Mass Effect games?

Whilst this can hardly be called good, you'd want to think that at this late stage in development, the vast majority of plot, setting and dialogue writing would be complete.