5 is too little.

TLoU:

- The whole damn game.

RE:

- The whole atmosphere.
- Crimson Heads.
- Wesker's betrayal.
- The final battle.

RE5:

- Lost in Nightmares.
- Shadows of the past.
- Two on two.
- The whole last chapter.

RE3:

- The whole atmosphere.
- Nemesis introduction.
- All of Nemesis encounters.
- RC destruction.

MGS4:

- End of third act.
- Rex vs Ray.
- Liquid Ocelot vs Snake.
- Epilogue.

MGS3:

- Big Boss's torture.
- Shagohod's chase.
- The Boss battle and death.

MGS:

- Mantis boss battle.
- Fox's sacrifice.
- Liquid's boss battle.

MG2:

- Fox vs Snake.
- "Killing" Big Boss.

FFVII:

- Nibelheim flashback.
- Aerith's death.
- Zack flashback.
- The final battle.

Complete off topic but alot of people's posts are blacked out. Is it to prevent spoilers or something and who blacks them out?

I don't know about you, but I'd get goosebumps every time I play someplace cold. Or, go anywhere cold, for that matter.

That aside, I don't really get goosebumps when playing. Maybe a smile on my face, or some sort of feeling of contentment, or an adrenaline rush, but never goosebumps. The closest I got there was when I played FE: Radiant Dawn.

A top 5 is hard but here are a few moments:

-Restoring an area in Okami. The music and the pictures still give me goosebumps after seeing it countless times already.
- Wonderful 101. The final battle. No explanation needed.
- The end and the credits of Dishonored. Basically the same explanation as Okami. The music and the scenes you get to see are very emotional (for me at least) + the music when the credits start to roll nails it.
- Final scenes of Metal Gear Solid 3: Snake Eater.

I'm sure that there are more but those are the one that come to my mind right now.

5. Pokemon Yellow/Pokemon Ruby

The champion battle music in these games was incredible. Set the tone amazingly for an epic battle.

4. Super Mario Galaxy

The moment the game began I knew I was in for something incredible, just the orchestrated title music alone is enough.

3. Pikmin 2:

Facing many of the bosses was just an incredible time in this game. Empress Bulblax, Burrowing Snagret and so many others had me fidgeting everywhere during the game.

2. Fire Emblem Fates

The storyline death of members of either your adopted or birth family is done incredibly well. The entire atmosphere of the game gave me goosebumps too, so polished.

1. Pokemon Mystery Dungeon (Red/Blue, Darkness/Time/Sky, Super)

The endings to the first two pairs of games are without a doubt my favourite moments in gaming. I've never played another game as emotionally-effecting as Darkness/Time and that's a pretty huge thing coming from Pokemon. Super didn't quite live up to the first two sets of games for me, but it completely threw me with the ending, I thought it would be like the first two, but nope. (Spoiler: YOUR PARTNER IS MEW AND LEAVES YOU (for a while, anyway) AFTER THE CREDITS.)

Bioshock has been mentioned - but you've left out the most draw-dropping moment of the entire series.

Would you kindly update the OP?

5. Shadow of the Colossus

- Ending

4. The Legend of Zelda: Majora's Mask
- The game's theme and the music. Especially the music in Ikana Canyon.

3. System Shock 2
- The PLOT TWIST, omfg

2. Silent Hill 2
- The whole game itself.

1. 999: Nine Hours, Nine Persons, Nine Doors
- As you progress through the game.

The ending to the last of us. It absolutely astonishes me how perfect that ending was.
The prologue to MGSV: TPP. I don't what it is, but I'll never forget that sequence. It's just so disorienting the entire time. I loved it
Spoilers on MGS3, I guess if we can still call them that.
When you kill the boss. That's one of the most powerful moments in any game in existence.
The initial descent into rapture in Bioshock.
John Marston's death in red dead redemption.

There is also the end to MGS4, and the end of act 3. 

Final Fantasy 7 - Never had seen anything like it before, the cutscenes, Aeris's Death scene, The Music, The Characters and their relationships, i couldnt put the game down and couldnt wait to get home from school to play, i even spent summer days inside playing.

Bayonetta 2 - First fight with the masked Lumen Sage, so fast paced and had to stay so alert, the game in general just action packed from start to finish.

Sonic The Hedgehog - Got it with my Mega Drive for Christmas, the game was amazing to me, the first time i heard the music to the Green Hill Zone i was hooked, still my favourite Sonic Game to this day.

Many more amazing experiances but there the ones that stand out when i think back the most, obviously when i first played a video game on a Amstrad CPC 6128, The Legend Of Kage was my first game, then games like Head Over Heels and Arkanoid.

In no specific order.

1: Panzer Dragoon Zwei theme. Being a huge fan of the Saturn trilogy of games, the music in the second one set an amazing mood for it.

2: The final run in super metroid. The sense of leaving the planet after the final run (and also saving those creatures on the way) was pretty special.

3: The "twist" in Panzer Dragoon Saga. When the main character Edge realize that things have not been what he thought they were, I just stared at the TV.

4: Zelda theme: How you can create something so beautiful with so little resources on Nes is beyond me.

5: Halo theme: The music that gives me goose bumps everytime I hear it since it, from the very beginning, is connected with such a special experience.