Quite a few, actually. Off the top of my head though:

Counterstrike

Team fortress 1 and 2

Unreal Tournament and UT 3

Diablo 1,2 and 3

Arena, Daggerfall, Morrowind, Oblivion, Skyrim

Baldur's Gate I and II

Icewind Dale I and II

Mount & Blade

Heroes of Might & Magic I, II, III and IV

Might & Magic 6, 7 and 8

Betrayal at Krondor

Final Fantasy VII, VIII, IX, X and XII

Gran Turismo 1, 2, 3, 4 and 5

Swat 4

Call of Duty 1 and 2

Borderlands 1 and 2

Deus Ex

Gothic II and III

GTA 1, 2, 3, Vice City, San Andreas and IV

Dungeon Siege 1 and 2

Eador: Masters of the Broken World

King's Bounty: Armored Princes and Crossworlds

Neverwinter Nights 1 and 2

Risen

Sacred

Starcraft I and II

Warcraft I and II

Civilization 2, 3 and 4

Colonization

Sim City 2000 and 3000

Terraria

Worms

Super Mario Bros 1, 2 and 3, Super Mario 64

Mario Kart 64, Super Mario Kart

Zelda: Ocarina of Time and Majora's Mask

Resident Evil 1, 2 and 5

Goldeneye 64

Lands of Lore 1 and 2

Ultima Underworld: The Stygian Abyss

Temple of Elemental Evil

Stone Prophet (Ravenloft)

Carmageddon 1 and 2

Delta Force 1 and 2

Can't remember any more, there are probably a few more I haven't mentioned though. And; yes, I like to get games with lasting value and I replay the classics fairly often.

post em!!

Pokemon Gold, Skyrim, Xenoblade Chronicles, Oblivion, Brawl, Mario Kart Wii all had playtimes up to and over 300 hours.

Games over 100 hours include Animal Crossing: New Leaf (presumably Wild World too), Fire Emblem: Awakening, Ocarina of Time, Twilight Princess, Mario Galaxy (through repeated play-throughs), several Advance Wars games and probably more.

EDIT: Skies of Arcadia Legends also springs to mind as definitely being over the 100 hour mark. I played it once a year up until about 2010, with around 40 hours as an average play time... so yeah. Still one of my favourite games. May have to dig it out and give it a play sometime this year.

FF7
FF10
Demons Souls
Dark Souls
Counter Strike (thousands of hours here)

pokemon yellow, HG, W2, X.
DKC3,
zelda OoT, WW, SS
KH 1, CoM
Ragnarok
Xenoblade

I could speculate on games I know I played alot, but instead I'll only list the games I know for a fact that I've played over 100hours.

-World of Warcraft, I played over a 100days! Yeah, this is not a typo, not hours, DAYS. I know for a fact that I've reached that benchmark loong before quitting the game, I speculate I've reached between 130 and 150days of gameplay if not more... And that is only for my main character (I talk like I should brag about it, but I know I should'nt)
-Pokémon X, this game last time I've checked I was at 87hours. Not sure If I've reached the 100, but if I have'nt, I will for sure really soon. Also I speculate I've done it with Blue and Gold and probably Saphire also.
-Kid Icarus Uprising.
-Warcraft 3

There is probably a few more games, but It would be speculation. I'll need to check and I'll edit my list in consequences. 

DAMN, MAN!

RuneScape, MapleStory, Rumble Fighter, and League of Legends.

Outside of MMOs and the sorts;
Star Ocean: Till the end of time and pokemon emerald...not sure how i got 100 hours on pokemon but i did.
I got pretty close to 100 in dissidia duodenum Final Fantasy. Fantastic fighting game, I could spend hours on end on it.

Final Fantasy X.

I was so pissed when I got to Zanarkand only find out I was only a third of the way done with the game. When I beat the game, got all the summons, and won the blitzball championship - I sold the game. Because I still couldn't stop playing it! lol