Seems like some game sites have already tried it out.
From Kotaku:
HANDS-ON IMPRESSIONS
Nintendo let me try two working units of the 2DS at their offices in New York City earlier this week. Both appeared to function just fine, though the screens seemed small to my eyes, given that I've become comfortable playing with the 3DS XL and its nearly double-sized screens.
The most notable difference between units isn't really the lack of 3D graphics but the form factor. While it may appear ungainly and certainly doesn't fit in a pants pocket, it felt good in my hands. The circle pad, d-pad and face buttons were all easily accessible. Their placement on both sides of the upper screen directs one's focus more squarely on the upper screen, creating a little bit of the feeling of playing a game on a Wii U GamePad or original Game Boy Advance.
I was not able to test the comfort of playing a game that makes heavy use of the touch screen, the lower screen. But the fact that a 3DS XL-sized stylus ships with the system should help hand comfort. It also helps that the system is fairly light—lighter than the 3DS XL—and easier to hold with one hand.
The shoulder buttons on the 2DS are thicker than those on the 3DS and have a concave depression. That curvature makes the system easier to cradle and also helps with any one-hand play, presumably comfortably freeing the player's other hand to wield a stylus for touch-based games.
The overall build of the machine feels solid, but the design does look lower-budget. There's a lot of plastic to this thing with relatively little surface of the unit devoted to screens. Compare that to the 3DS XL, Sony's Vita or any popular smart phone and tablet, and it feels less than cutting edge. It does feel sturdy, though, so despite its sliced-bread shape, it doesn't feel like it will snap.
It's probably best to consider the 2DS in the same league as other experimental off-shoots of Nintendo's handheld line. This isn't the obvious improvement that the DS Lite was over the DSi or the 3DS XL over the 3DS. This is more akin to the oddities like the Game Boy Micro or the DSi XL... hardware that'll work just fine and is targeted at a different group of gamers that may prove to be a small niche or an underserved crowd waiting for a system they'd otherwise have missed.
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