I've not played RE4. But I tried playing RE5 and I think that game is a big shitty mess.
From my experience with RE games, which sums up to RE1 and RE5, I don't see how a RE game could come close to the Last of Us.
But I have a very biased opinion, and not much experience with RE games.
Been away for a bit, but sneaking back in.
Gaming on: PS4, PC, 3DS. Got a Switch! Mainly to play Smash