44. The Elder Scrolls V: Skyrim (2011)

This is the first new arrival on my list over the past couple years.  There's so much to do in the world that it's incredibly easy to get sidetracked from any quest you are on.  Running across giants and dragons is exciting for a while.  Primarily I like this game, not because of the story or combat, but because of the exploration and different dungeons.  The random quest generation allows you to pick up the game whenever you feel like it for short bursts. The different skills allows the game to be played in almost any manner desired.

Yes, Lakuti pretty much saved 3D gaming!

My #43, guessed by Kresnik, is Excitebike 64. Of all the great Nintendo 64 games, Excitebike 64 is probably the most overlooked. It’s neither as sexy nor as famous as titles like GoldenEye 007 or Super Mario 64 but it’s an essential game in the N64 library and the best racing game to appear on the system, surpassing fan favorites like Wave Race 64 and F-Zero X. Like its ancestor on the NES, Excitebike 64 is a motocross racing game that combines a realistic physics engine with some arcade embellishments. Players can choose one of six riders and compete against the CPU or against three friends in twenty indoor and outdoor tracks. Excitebike 64 features several special tracks, stunt courses, and a track editor, which allows players to build their own personalized tracks from scratch.

My clue for #42:

The first two words of this game = the first two words of two upcoming PS3 exclusives. The third word = a Marvel superhero.

it's because Lakuti was a phsical thing in the game, like he couldn't go into solid objects which was what gave sonic adventure those lovely really fast portions with the camera behind a wall or looking at something else until you hear that noise of sonic's death.

But! My 43 is indeed Mario 64 I had a playstation at the time and a friend of mine got an N64, called round his house played this, went right to a game store and bought an N64 that day, Just mindblowingly good platforming, boss fights, power ups and amazing textures in the n64s insane 4kb texture cache! MINDBLOWING.

hint for 42. A game with far fewer than 151 characters that replaced the phrase handheld gaming with "playing gameboy" there is 7 characters in total in the game.

43. Duke Nukem 3D (PC)

Duke Nukem 3D is by far the most childish game on my list, which is funny given it's one of the more 'mature' ones at the same time, but hey... I was 13 when I played it, so right at the perfect age to appreciate it. I haven't played it since then. Would it make it anywhere near my top 50 today if I played it again now? I don't know, but based on how much I enjoyed the game back then, it's worthy of a place.

Game 42 was the final entry in its series before a major shift in perspective changed everything.

warcraft 3 or the frozen throne? also I think Duke Nukem was one of the first pc games I ever seen remember laughing my ass off as he tore that boss's head off and got the newspaper out. Ahead of its time.

So 43 was The Curious Village. 42 is a very early PS360 game which really redefined a lot of things which are just natural in games today (for me at least), even if they weren't executed brilliantly. A sequel was released a few years later, but was not so good in my eyes. A 3rd game is due early next year.

Dead Space?

43. Pokemon Stadium 2, N64 (2001) Nintendo/HAL Labs (Last year, 41)
This was during the height of my own personal Pokemania, and the last Colosseum type game i bought (skipping Coloseum, XD, and Battle Revolution), so it has a special place in my heart. As unbalanced as the earlier Pokemon games were, nostalgia points for all the hours spent strategizing, battling, or just dicking around with the mini-games (also the free mystery gift! And a girl to fight in that one room in Veridian!) gets this game the 41 spot.

For my 42, there is a certain game, Japan-only direct sequel to what used to be the best-selling game of all time. It was introduced to America in a 4th generation port, and also as bonus content in this game during the late 5th generation.

43rd - Earthbound/Mother 2 (SNES, 1995)
One of the most witty, funny and intelligent RPGs ever created, Earthbound is a cult classic that every RPG fan should play at least once in their lifetime. Filled with a plethora of cultural references, mostly to western pop culture (The Beatles are one of the biggest focus of these references), it also parodies a lot of clichés of the genre and American culture.
Boasting, as well, one of the best OSTs in any RPG, Earthbound is also an unique sound experience, every location having a very distinctive and memorable BMG like Happy Happy Village, Moonside or Magicant.
The game does have it's short comings though; it's very simplistic approach in it's core gameplay mechanics, akin to early Dragon Quest games, which not all throughly a bad thing, it felt a bit like a shortcoming to what the game could accomplish. Also, the main characters suffer from little to almost none character development, in constrat to the main villain, who undergoes a rather large amount of layers of character development, making Pokey one of the most memorable elements in the game. 
A final shout to the final boss battle of the game: Definitely one of the most bizarre experiences I've ever had in a videogame ever.

      

Number 42 is a sad entry because Rosencrantz and Guildenstern are dead .