Altough I would love to see Mass Effect taking the GOTY awards again you shouldnt count Resident Evil 6 out. But it looks more and more like very slow year.
I'd toss The last of us in here but I don't believe in a 2012 launch :P.
Last year was the biggest year in this gen seriously (when speaking acclaim etc). Its only natural that the next year is a tad slower. I still had a bit higher expectations for 2012 though I admit.