Dance Central: Best motion controlled game (my current addiction)
Alan Wake: Best atmosphere/Exclusive graphics
Dead or Alive Xtreme 2: Horrible game. Best virtual boobies. I got it for maybe $10
Halo 3/Halo Reach: Best FPS's
Gears of War 2: Possibly my favorite game this gen.......don't judge me.
Fable 2/3: Most addicting (especially if you can find someone to go online with you)
Lost Odyssey: Best JRPG this gen (hands down, in my opinion)
Splinter Cell Conviction: Best use of Michael Ironside
Viva Pinata-Trouble in Paradise: Best time waster
Ace Combat 6: Best dog-fight simulator
Dead Rising: Best use Frank West (HD, only)
Halo Wars: Best RTS
Bonus: XBLA list--some may be on PC. Hell if I know:
Kingdom for Keflings/World of Keflings: Best Animal Crossing ripoff (it's addicting as hell--I'm playing both at once!)
Beyond Good and Evil HD: Best last gen revival
Comic Jumper: Most funny (the heir to Earthworm Jim's throne?)
Crash Course: Most free.....(one could argue that Harm's Way, Hexic HD, and a few others are equally free, though)
Geometry Wars: Purest gaming experience
Limbo: Most brain busting
Pinball FX: Most nostalgic (Pinball FX 2 is free, btw)
Shadow Complex: Best downloadable game, ever.
Splosion Man: Best platformer
Super Meat Boy: Most meaty?
The Maw: Most family friendly
Uno (with XBL Vision Camera): Most likely to see real boobies from horny girls on the internet--has a few features not found in other versions, too.
---it was tough not tossing in some of the other XBLA games and I know I named a lot more than ten. Sorry bout that.