I hope borderlands becomes a franchise

Yeah its hard to argue with Mass Effect being the #1 spot. I'd put Gears as a close second and Uncharted 3rd. Not a big fan of L4D.

My list.

7. No More Heroes

6. No More Heroes

5. No More Heroes

4. No More Heroes

3. No More Heroes

2. No More Heroes

1. No More Heroes

For me, it would be the following in no particular order:

- Phoenix Wright

- Uncharted

- No More Heroes

- Wii _____

- Bioshock

- The World Ends With You

- Scribblenauts

My top 3

Viva pinata

Mass Effect

Alan Wake

Bioshock should be #1. 

I would take away Gears of War and I would call that a perfect list. 

My list (series that I've played):

1) Uncharted

2) Assassin's Creed

3) Resistance

4) LittleBigPlanet

5) Heavy Rain

6) Gears of War

7) Mass Effect

Worth mentioning: BioShock, Dragon Age, Left 4 Dead, Portal

No "Dead Space" and no "Dead Rising" really cheapen this list.

honestly, i can only agree with Mass Effect in that list.  if bioshock infinity is as nice as the first then i would probably include it too.

games from the list i dont own and cant speak on:  professor layton, Gears of War 1.