I currently am on a full Renegade playthrough of the Mass Effect Trilogy. Mass Effect 1&2 were relatively bearable, but oh man Mass Effect 3...
I just finished Tuchanka.
I killed Mordin.
I sabotaged the Genophage.
I doomed the Krogan Race to extinction.
Wrex is so happy right now, not yet knowing that his best friend betrayed him.
Great job, Bioware. Now I feel like the biggest scumbag in the Universe :(