Holy shit FF13 won by a MASSIVE margin last month. Stop voting for it everyone!
1) The Last Guardian
2) God of War III
3) Uncharted 2: Among Thieves
4) Ratchet and Clank Future: A Crack in Time
5) Modern Warfare 2
All PS3.
EDIT: I have no anticipation for massively delayed games, so goodbye BioShock 2.