The NES has a ton of games/franchises that deserve a proper comeback with today's formats. *some of these have gotten sequels in more recent times, but I'm talking about a complete franchise reinstatement using existing tech and by a capable developer.
Crystalis
Faxanadu
Little Nemo Dream Master
Shadowgate
Maniac Mansion
Contra
Final Fight or Double Dragon
Blaster Master
Boy and His Blob
I also have a guilty pleasure request for Cybermorph on the Atari Jaguar with similar tron-ish, mystical, sci-fi, highly artistic graphics.
Oh, I almost forgot Black and White on the PC!