Nintendo doesn't have global appeal, on emerging markets (except China) they are virtually non-existant. In most of the developing world Nintendo relies on third-party distributors which are very unreliable and change constantly and stop selling their products whenever they feel like it. On the other hand Sony and Microsoft distribute their products directly in the third-world, even if they lose money, because it's very important for their products to be known globally.

Well MS can't kill them with Xbox One if NX again is different and unique with games that are not available on Xbox One. For instance how exactly MS can kill NX handheld that will be probably have have integration with NX home console!?

Yup, change handheld market is one of the reasony why they probably are going for unified platform. We already know their next moves, mobile games, themed parks and similar, and very likely unified platform.

It will kill the bone with the nx

NES and SNES  were victims of Nintendo's piss poor European strategy of the past, quite frankly Nintendo's attitude to Europe in the 80s and 90s was simply that it was a "bonus" market and that the main focus was Japan and USA. They did not view Europe seriously back then. 

Nintendo has thankfully improved in Europe since then, the problem now is though that the Wii U console was simply not a very well thought out console. 

They can beat Microsoft in Europe, I don't have much doubt about that, it's just a matter of having a strong console product that can do it. Another weak console or ill-conceived console though and no. 

While they won't play Sony there, they need to have a product that can credibly stand next to the PS4. 

You need to temper your expectations my friend, the NX won't be as powerful as you think and here's a couple of reasons.

1) The NX is releasing mid generation, so price is key. Since the PS4 and to a lesser degree the xbox1 are already entrenched in peoples minds, the NX needs to sell itself as the secondary console, at least to ride out the generation till the next one starts, so a cheap to make, cheap to sell console is supper important. Perhaps the NX will cost $150-$200 like the Nvidia shield.

2) NX will be powered by mobile hardware as mobile tech has reached the point where it can deliver Nintendo type graphics with no problem. Power is not important mid generation as their simply isn't enough of a jump to make a difference, and releasing the NX for $350 with the same PS4 hardware is redundant because it didn't work for the WiiU so why on earth would they try now when the PS4 is so entrenched in Peoples minds.

3) Why Mobile hardware, because this allows the home console to be a derivative off their portable hardware, Nintendo can then make 1 game which works on both platforms as the architecture would be the same, just like Iphone with Apple TV and its software eco-system. This actually expands the install base for all their software, it also allows for easy and cheap unified development, and allows them the potential to leverage mobile gaming, whether it be making mobile games with Nintendo IP's or creating new 3rd parts relations with mobile developers and indies.

4) Tradition 3rd party has essentially abandoned Nintendo, unless Nintendo starts money hatting I don't see them gaining any traction, so why bother, why not instead try foster new relations with mobile developers and use them as Nintendo's new 3rd party along with indies/japanese deves. It's clear that this is what Nintendo are aiming for with their DeNa venture.

5) That recent comment by Nintendo's CEO about them not abandoning the WiiU is nothing more than damage control, do people remember the 3rd pillar strategy they had when the DS launched 4 years after the GBA was released?....didn't take long for Nintendo to ditch the GBA and the gameboy brand, this is what they are doing here with the WiiU.

If anyone disagrees with the above points, then explain to me how making a PS4+ level box, selling it for $350 mid generation with essentially no tradition 3rd party support in a time where PS4 is so entrenched in people minds, explain to me how this is ever going to to be successful?
Personally I just don't see it, on the other hand a cheap $150 home console based on mobile parts which can leverage both the NX portable and the apple/android ecosystem seems like a win, even if it doesn't sell gangbusters, it's affordability and the fact that it will have all Nintendo games will make it a perfect secondary console for anyone who already owns a PS4/xbox1 and Steam, it would also make an excellent first console for many young kids since I believe all games will come on cartridge, 1 cartridge works both on NX home and NX portable (like I said NX home would be a derivative of the NX portable).

Anyways this is my educated prediction, obviously none of us will know until Nintendo themselves reveal it but this is honestly how I think things will play out with the NX. I suppose it's better to go into the NX reveal with low expectations and possibly be blown away than go into it expecting the world and end up disgusted as fuck.

Still only 1 out of 6 Nintendo home consoles have been a major success, to assume they can beat Microsoft head on with nothing to back up the thought is niave.

If they intend to replace the Wii U with an Ouya they have already failed, even more so if it is another 8th-gen console to bide time for the next generation. If they do this they will end up like Sega. Nintendo should have kept the Wii U on life support until this generation ends.

You don't assume anything. In fact none of this is assuming anything, Nintendo needs to get away from that mentality and WORK their asses off for a change rather than expecting miracles to fall into their laps. 

Europe does not by and large accept "speciality" or "secondary" consoles either. It needs to have the mainstream games that everyone wants. 

But generally I think the idea that they have that they are just going to cede marketshare to Sony AND Microsoft (both of them) and not even put up a fight ... honestly I don't think it works. It only works if you can pull a Wiimote miracle controller out of your rear end every generation and they can't do that, they didn't even invent the first Wiimote, it was invented by an American guy who tried to sell it to Sony/MS first. Where's Nintendo if that happens?

Why Ouya? Why not the Nvidia Shield?

The way I see it Nintendo has the games people like so this alone will make them more successful than the Ouya. Also at this rate they could probably deliver a more powerful console than the WiiU is with just mobile parts, and I think WiiU level hardware is more than sufficient for Nintendo to deliver their type of games with their type of art-style.

So if you could pick up the NX for $150 with the latest Nintendo games, which includes access to all portable titles, how would this be a failure like the Ouya? Hell i think it would be more successful than the Nvidia shield.

You may want Nintendo to keep the WiiU around till the next wave of console launches, but something tells me the platform is no longer profitable and why they are looking to replace it as soon as possible, this is usually what happens when software sales stagnate or drop off the cliff. I'm sure if software sales were really strong then they would of just kept going with it, just like Sony keeps going with the PSvita, strong software sales keep the platform profitable even if install base is low.