Kunio-Kun (River City Ransom, Crash 'N' the Boys: Street Challenge, Super Dodge Ball, Nintendo World Cup, and many more games that only came out in Japan). My favorite franchise ever. Somebody bought it all and was supposedly working on a Kunio Online game for Windows that would incorporate soccer, dodgeball, fighting, and everything all in one game, but the last I Heard was "it was going to launch in 2006." I think the series is dead, despite 1 remake for GBA and 1 for DS.
And... X-COM. Hasbro bought MicroProse (and the franchise), made the team work on 3 shitty spin-off games at once, and wanted to branch out to FPS games and action figures... and it didn't work out so well, so they fired everybody and kept the intellectual property. We will never see another X-COM again. ::weeps on his keyboard:: (Whoa, just looked it up, and Hasbro sold it to Infogrames/Atari, who sold it to Take-Two, who MIGHT... some day... make a new one. I mean... why'd they buy it? Crazy.)