No it won't. Infamous was nowhere near the game uncharted was. I loved uncharted, everything was done great except a little too much combat in the middle of the game. Infamous on the other hand, felt very repetitive, limited in scope, and didn't have an engaging story line/characters to pull you in.
It won't do any where close to what uncharted 2 accomplished. Uncharted 2 is perhaps the most polished, engaging, and brilliant game we will see this gen.
Fact: Earthbound is the greatest game ever made