Eh I cannot say anything besides I like predicting. :P

Thus far 8 PS3 titles have broken the 3 million barrier so I see this as a good bench mark. These games can be exclusive or multi-plat so guess away.

My guesses are:

GOW III

GT5

Assassins Creed 2

Modern Warfare 2

FFXIII

FF Versus

Those are pretty much the only titles I can think of which is actually pretty sad.

Uncharted? The next Fifa? :/

Im being optomistic :)

There's no way GOW 3 & FF Versus 13 are gonna do over 3 million

anyway now for predictions:

AC2, MW2, GT5 (in a heartbeat), FF13, Uncharted 2 has 50% of a chance

As we are predicting FF Versus 13 (which won't come out before 2011) I'm gonna say the next COD from treyarch & the next GTA game

Modern warfare 2.
Assassin's creed 2
Gt5
Gow3
Uncharted 2
FF13
FFvs13
Fifa10

one more for the list:

Metal Gear Solid Rising

^
what changed in FIFA that would increase its sale by 35% from 09 to 10?

Add UnCharted 2 and Metal Gear Solid: Rising.

Bigger install base, and a probable Pricecut/Slim

Well it increased 31.5% 08>09, and 09 still sold another 12k last week.  But I think hitting 3 million with 10 will be pretty unlikely unless PES is pretty bad and the fans finally jump ship to fifa.