There are certain games I can beat over and over and over again and they're still a blast.  Mario 64, most FPS games and Mario Galaxy come to mind.  There are other games that I love them, but once I'm finished I think back to some parts of the game and can't even fathom having to go through all of that all over again.  Maybe it's just me.  Here's an example.  I absolutely LOVED Metroid Prime 3 on the Wii, but when I was all done, I just couldn't imagine having to do all of that exploring, backtracking and collecting all over again.  I had to trade it in for credit.  The same thing happened to me with Zelda: TP.  Now that I think about it, any game that has a set level progression I can play over and over again, but epic expansive titles wear me out after one playthrough.

Anybody else?

yes happens to me all the time thats why i play the games on the hardest difficulty the 1st time i also take my time and unlock everything i could through one play through i guess it has to do wit my age i dont think i had this problem wen i was younger

MGS 2
Persona 4
FFX
Valkyria Chronicals

Happens to me ALL the time.

But I can play every Mario Game over and over again, especially Galaxy.

happens all the time with me but there are a couple of games i can play over and over again

yes, it's amazing how a lot of games have at least one part that I don't wanna play again. I guess that was one of the good things about Goldeneye back then, I could choose NOT to play on Bunker 2 or Control!

Final Fantasy XII
Elder Scrolls IV Oblivion
Dragon Quest VIII

Usually RPG genre based games I dont go back and play through again

MGS 4
Assassin`s Creed
Half-Life 2 and the episodes

And i finished Resistance 2 five times and Bioshock three times

Now that MGS 4 is with a friend i really feel like playing it though, lol...

The only game so far was SMB: Lost Levels (especially at world 6 *shrugs*)

Oblivion.

Kind of MGS4 as well, but I played it twice and was too exhausted to continue.