Metal Gear Solid - Psycho Mantis
Honorable Mentions:
Metal Gear Solid 4 - Liquid Ocelot
Shadow of the Colossus - Gaius (3), Avion (5), Malus (16)
God of War II - Colossus of Rhodes
Contra: Hard Corps - too many awesome bosses to list
Metal Gear Solid - Psycho Mantis
Honorable Mentions:
Metal Gear Solid 4 - Liquid Ocelot
Shadow of the Colossus - Gaius (3), Avion (5), Malus (16)
God of War II - Colossus of Rhodes
Contra: Hard Corps - too many awesome bosses to list
MGS - Psycho Mantis
MGS3 - The End
MGS4 - Liquid Ocelot
Suikoden 2 - Neclord (just for the music)
Baldurs Gate - Sarevok
More to come, but cant think ATM
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Zelda Tp: Final boss & Dragon monster
Zelda Ww: Final boss & molgera battle
Skies of arcadia: Final boss: Ramirez

Tough choice.
I'm thinking Omega just because he's the most badass thing in Mega Man history. I never get enough of fighting him.
So I guess my choice is Omega from Mega Man Zero 3 and Mega Man ZX.
I am Washu-bot B, loyal servant of Final-Fan, the greatest scientific genius in the universe!

Gannondorf in Twilight Princess i loved it that you can clash with him, sword to sword.
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