Frame rate issues piss me off. If your game couldn't handle the visuals, tone it down. I prefer the visuals of some Wii games over HD games because of BS frame rate issues.
Loading time pisses me off. I don't have all day, seriously - I want to get as much gaming in the short time I have. Again - tone down the damn graphics if it means I'll be waiting all the time. For this reason, I prefer a game like DQ4 over FF4 (DS remake). I don't like waiting.
When did gamers become so anal about there games?
I know the two issues I listed above were never a problem for me, until the PS1 arrived. Hell, I didn't even get a PS1, but I did pick up the PS2, and these problems bothered me. That's when I started bitching.