The Rachini wiped out Wrex's race - genocide. Wrex was pissed about it - who wouldn't?

A lot of changes happen if you kill her - or set her free. I remember going to a new planet and talking to the soldiers when we got plummeled by several Rachini. I counted at least 20-25. The next time I did a playthrough, I didn't kill her and never saw the planet again.

You definitely have to be weary of your actions.

I actually think you need about 4 playthroughs to get the full experience. And not just as one player - but an engineer, commando and the like.

BW always packs their games with replay value. Try playing different classes, different backgrounds (colonist, earther, etc - each has a different quest), and different alignments.

Rule of thumb:
Always put as much as you can into the social skills in a BW game.

I started allocating all my points to charm after I got a sucky outcome in a sidequest on Noveria because I couldn't persuade some guy to agree to something.

It was well worth it in the end. You can even convince Saren not to fight you.

Hmm.. I should definitely try this game sometime soon.

You have to be careful about investing in charm, you will get auto upgrades to it at some points, related to gameplay and storyline.

I tell you the coolest time I had with the charm/intimidation was on Ferros, when you are talking to some dude who just left workers behind to save his hide.

The dialogue was priceless.

"No one would miss you if you came up missing!"
Mad Skillz Shephard: "And no one would miss you either."
BAAM!

I ROTFLMBO for a few minutes thinking about that. No one dared to get near me.

No, Wrex's race was found to be the ones that were capable of defeating the Rachini and they did just that. They were perfect for ending the Rachini wars because they could quickly reproduce and are very tough to kill.

What happened after the defeat of the Rachini was that the Krogan aggressively expanded their population and rebelled. Thus, the Turians developed the Genophage which makes only 1 in 1000 Krogan births successful.

Talking about Wrex, I actually charmed him into staying in the party. It was kind of cool because I didn't want to kill him.

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Playing it over again is fun, but be ready to go through a headache by dealing with the inventory. Everybody will be wearing the default equipment again and you'd have to wade through all your stuff just to get everything back to normal. With the crappy inventory system.... ugh.

I stand corrected.

Wrex was blasted the first time around - but I did charm him to stay. That was awesome. This game, worts and all, really amazes me.

I just hope Shephard and Ashley are still kicking it in ME2. And I hope she's down and won't have to try so hard next time.

I barely ever finish games these days, and I have played through Mass Effect in its entirety four times and will doubtless play it again. It is also the only non-XBLA game in which I have completed all of the achievements.

Increasing the difficulty level will also affect your game experience during subsequent playthroughs (I believe Hardcore is unlocked upon finishing the game once, and Insanity upon finishing Hardcore). I recommend trying it.

thats just mental - i've never seen an end of game boss that can be wn by talking him to his senses.