I see the nominees being: MGS4, Little Big Planet, Gears of War 2, GTA4, Fallout 3, Super Smash Bros. Brawl (which i think will be a nominee with no chance to win, it just doesn't bring enough to the tables but the best that wii has got for GOTY nominees this year)
Personally, I see MGS4 taking home most of the awards. But I'm biased in that matter. I think GTA4 is going to take home more awards than people would like to think unfortunatley.