Wii:
SSBB
Galaxy
RE4
No More Heroes
Zelda
Honourable mention goes to Medal of Honour: Heroes 2, Metroid Prime 3, and WarioWare: Smooth Moves
DS:
New Super Mario Bros
Elite Beat Agents
Nintendogs
The entire Ace Attorney series
Animal Crossing
Honourable mention: Metroid Prime, Mario 64 DS and Hotel Dusk