#41 - Transistor.

I have no idea what that is, seems like you're running out of memes. But yes it is Bloodstained.

50 - Joe & Mac (I don't think anyone guessed this one but I posted it already on the main thingie.)
49 - This Controversial entry in a long-running series garnered plenty of criticism, likening it to Britan's exit from the EU
48 - This is the kind of game that's really only worth whatever you put into it and has a HUGE following on Youtube to this day.
47 - This sequel is what reignited my love for Rush and Megadeth.
- Something like 80% of this game's content was completely redone and available to play on two games higher in this list.
46 - This latest entry in a long-running series is a prime example of good platforming game design, but some people find it stale. I think it's possibly the best designed entry into its series (not my fave, though.)
45 - Witty woman goes in, homocidal psycho robot comes out.
44 - This sequel is what re-re ignited my love for Rush and Dream Theater
43 - you can kill Sasquatch, but it's not a triumphant kill.
42 - For the first time in this series, you can play a full campaign as the cooler, redder character instead of the blue boy with lemons. You could play as them in an earlier entry, but selectively.
41 - "un forastero!" *Throws an axe at you*
40 - Inspired by Ninja Gaiden, this linear 8-bit platformer turns into a 16 bit metroidvania around the halfway mark with Link to the Past inspired world swapping.

38) This series is seemingly well on its way to remaking all its games from the beginning. This was the second remake

37) ^Strangely enough this hint also work for this game. Only the remakes have been more split over the years for this series

#40 - The protagonist has a notebook and draws just about everything that happens in the game, from major events to random things.

More hints!

43) This game likes reversing things. Names, structures... It also has an overly convoluted spell system. When you think you've reached the end you might be in for a suprise

41) Get to the top of the mountain.

40) Unusual to this series and JRPGs in general, the MC of this game can wield not one but three weapon types

39) Despite being released in the same year its console was replaced, it might be the game people most associate with it

38) This series is seemingly well on its way to remaking all its games from the beginning. This was the second remake

37) ^Strangely enough this hint also work for this game. Only the remakes have been more split over the years for this series

49 is Super Mario Land 2, just played through it again last month!

46: Yoshi's Island

#47 - Resident Evil?

Incorrect, but very close...