I don't see what's the point of excluding the DS and PSP but whatever

1. Xenoblade Chronicles
2. Legend of Zelda: Skyward Sword
3. Legend of Zelda: Twilight Princess
4. Super Mario Galaxy 2
5. Ni no kuni: Wrath of the White Witch

difficult off the top of my head, but looking at some things here:

Xenoblade Chronicles
Fire emblem: Radiant dawn
Fallout 3
Tales of Vesperia
Mass effect trilogy

With this said, the Wii U should be considered part of that gen aswell and i'd add:
Xenoblade X

5 - Sonic Colors
4 - Super Mario Galaxy 2
3 - Dead Space 2
2 - Super Smash Bros. Brawl
1 - Alan Wake

In no particular order

Nier
Mass Effect Trilogy
Dragon age Origins
Dragons Dogma
Demons Souls

Though there are a bunch of other games I'd consider for the top 5 as well.

Fallout: New Vegas
Red Dead Redemption
Borderlands 2
Gears of War 2
Assassin's Creed II

Black Ops 2
MW3
Red Dead Redemption
Far Cry 3
Battlefield 4

The last story
Valkyria Chronicles
New Vegas
Arkham city
Dragon quest 9

* StarCraft 2.
* Crysis.
* Diablo 3.
* Bioshock.
* Dragon Age: Origins.

In no particular order:

Xenoblade Chronicles
Mass Effect 2
Super Mario Galaxy 2
Halo: Reach
Super Mario Galaxy

Zelda: Skyward Sword, The Last Story, Lost Odyssey, Gears of War 2, BioShock, Metroid Prime Trilogy, Geometry Wars 2, Skyrim, Arkham Asylum are all up there, too.