PC - As ever, the hydra of gaming: massive, all-encompassing, and downright overwhelming. Both in potential experiences and in the price it costs to keep a PC up to gaming standards. But it's still fun.
Wii - Most bang for one's buck, in terms of fun per dollar. Has quite a library of quality titles already, which seems easily missed by some. Then again, perhaps my standards are a little different, but I personally feel that 11 games worth owning at this stage in the system's life is nothing to turn one's nose up at. I haven't even half that many titles for my PS2 that came out between 2001 and 2002, yet I still loved my PS2 back when I got it in mid-2002.
360 - I see the potential, but I also see the more obvious problems: one, it's got hardware issues, and two, it's ultimately a PC with a controller instead of a keyboard and mouse. That said, it does have a few (currently) exclusive titles that do interest me, such as Eternal Sonata. Can't say much beyond that, as I don't have one and don't forsee getting one for some time, if ever.
PS3 - Even when you do get past the sticker shock, that's still a lot to ask for a game system. Potential is meaningless when it's not harnessed usefully, and as it stands, there are 0 PS3 games I'm interested in currently out, and only 2 on the horizon. Again, PS3 suffers from PC replacement syndrome, and since I have a gaming PC, I don't care for it.
DS - Solid library, interesting games, reasonable prices. A trifecta of victory, that. Little else needs be said.
PSP - While my DS and PSP libraries are equal in size, for the most part, my PSP library consists mainly of ports (both to and from the system). I'm sure that's not a good sign for the system, but if nothing else, the PSP is a great alternative to paying far too much money for rare PS1 games.