Definitely not on the handheld side of things and probably not for consoles. As long as Nintendo are in the green they will continue with consoles under current management.
But I do think some on here look at it too simplisticly thinking it would make no sense for them to drop consoles unless they were loosing tons of money. Its not always a case of profit vs loss, but more case of opportunity cost. If they took the billions they invest into console development each generation and pour it into something else, would they reap more profits? Software seems to be their main profit centre, so an investor might question how more money they would make if MarioKart was released on sony and microsoft platforms. Maybe there is a more rewarding investment out there other then consoles. Unlike Nintendo, Microsoft and sony do not make ''tons'' from their 1st party software and their prior success is built of making big install bases, reaping tons of 3rd party royalties, service revenue and eventually selling hardware for profit.