Zelda U reveal.
At least 2 more games that were not previously announced
Bayonneta 2 release date: May

He's one of the original 8 (only one missing too). He is guaranteed to be in the game, i just think they wanted to announce him with the Year of Yoshi alongside New Yoshi Island+Yarn Yoshi (and maybe one more Yoshi game)

GTA U
New epic Smash trailer, but the game will release only on holidays 2014, please understand.
N64 HD remakes

[1] Yoshi Yarn will be co-op with another playable character

[2] Fantasy Life (3DS) release date announced in the U.S

[3] Nintendogs U announced

That's kind of what I've been thinking would happen, too. It just makes me nervous, especially when all the others are announced! 

1. Cranky Kong for MK8
2. Cranky Kong for Smash Bros.
3. Year of Cranky Kong

....this sound so dumb, I can perdict Iwata announcing this because he so out of touch with gamer its perfect. Hey we were joking about Cranky Kong announement at the VGX so its possible.

1) Nintendo Buys Sega
2) Sega + Altus is Nintendo Exclusive
3) Nintendo Servers will be down due to hatemail

But in all seriousness its probably going to be:

1) Cracky Kong Annouced as a Smash Bros Character

2) X will be delayed till when Half Life 3 gets annouced

3) Wii Sports U

Yoshi has a better chance than every unannounced character! He's a Nintendo Icon. The chances of him skipping this game are the same as Zelda U being on Vita :P

No need to wrry, they are just hinted even more of year of Yoshi with this imo

This would be awesome lol

I predict there will be no surprises, like with most Directs.