Clue for my #40 - I can't think of any interesting clues for this.

Series is being revived in 2015 after 6 years of absence; and 10 years since the last mainline entry. This is the second in this particular part of the franchise.

Clue for #41: What comes between a kind of degree and the (original name of the) developers of the Neverwinter Nights MMO?

42. Ni no Kuni (NR)

A wonderful game that takes Pokemon's monster collection and evolution and wraps a different battle system around it.  Complaints about AI aside, the battles are solid and switching between your characters is used to crucial effect.  There is plenty of game content that varies quite a bit so if you ever tire of doing something you can find another task to work on. The contributions of Studio Ghibli are readily apparent in the story and gorgeous visuals.  On top of that, the Wizard's Companion is a great way to make the information about the world of the game available without relying on experimentation or strategy guides and contains loads of fun information to read through. This is the only game I've ever gotten a platinum trophy for, so I think that says a lot.

Hint 41: Escape after nearly being eradicated by an eye beam and make sure to save two helpful creatures on your way out!

Super Metroid.

Super Metroid.

*edit* 

Late.  Didn't realize there was another page.

Hint for 40: In this RPG, I had to save my globin many times.

Number 41 is Demon's Souls.

Hint for number 40.

Finish lines don't determine the winner in this reboot of a racing game.

Could it be Mario and Luigi: Bowser's Inside Story perchance?

You bet your globin it is.