Mass Effect 3, and Halo 4

MGS3, and MGS4.

Also MGS5, when they say is going multiplataform.

Ico.

I tried, but I just couldn't save Yorda. Arrrrrrrrgggggghhhhhhh.

Army of Two. Emotional stuff.

Shadow of the Colossus, Lost Odyssey and The Last of Us all got me teary eyed, but I've never really cried. I don't think any game or movie has the capacity to make me do that. Perhaps I am holding myself, but whatever.

The last two I can think of was Red Dead Redemption, but like others have stated, more mad/sad/outraged.

The most moving game I have played in a long time was Halo: Reach. Just leaves you sort of devastated at the end. Really well done and moving.

I just sat there and watched the full credits.  It was like the ending of a really good book or movie, where you know something is different now.  You see things differently.

 Interesting, I felt that the progression of Halo Reaches character development killed it for me so when teammates died, I didn't really care

Halo 4 is a huge step up storywise compared to Reach and I thats 100% because of the fact that Bungie was replaced to me.

I've never openly cried or wept while playing or experiencing a video game, but several games have gotten me teary-eyed. 

Xenoblade Chronicles-After more than 100 hours I was SO invested in all of the characters and the entire story that leading up to the final battle and ending there were several times that I teared up: When Melia's brother dies and then encourages her in a personal vision to lead their people and then Riki was able to hear it too. When Gadolt sacrifices himself and saves the group from a massive blast, shortly after telling Reyn to look after Sharla for him. Pretty much the whole ending sequence, but especially when Fiora appears and has her normal Homs body back at the very end.

Skyward Sword-When Zelda seals herself inside the crystal and tells Link that she hopes he'll come wake her up, after calling him "sleepyhead" and joking about his love of sleep for the entire first half of the game. Also when Fi's purpose is complete and she goes to "infinite sleep" inside the Master Sword...I know people didn't form an especially strong attachment to Fi, but the music is SO POWERFUL at that moment...and it's even more profound if you think about all the times you've used the Master Sword in the other games while the music is playing and the scene is happening, realizing that she's been in there and with you all along. 

Twilight Princess-When Midna shatters the Mirror of Twilight, closing the connection between the two worlds.

No game has made me cry yet.

Many have moved me, but never to the point of tears.

I cry quite easily at movies, however. King Kong '05, ET, The Land Before Time, all got me teary.