"After each of the first television season’s 13 episodes, a similar series of missions will be introduced into the game, and then retired by the time the next episode starts. After an episode about a plague, for instance, players will have to figure out how to cure the pandemic."
"Because the first season has already been shot, the interactive relationship is mostly an illusion. The plague on “Defiance” will be cured, even if the game players in Defiance unite by the thousands and refuse to be virtual Jonas Salks. But small background touches, via computer graphics, will be affected by player actions in the first television season: a character who appears on a wanted poster in one episode this season, for example, will be determined by what happens in the game."
I think Quantum Break is aiming a little bit higher than to put a mission about "go kill x number of monsters" when those monsters are talked in the series. That's more like an uptade or a timed event which has been done to death in MMORPGs rather than "interactivity between TV series and videogames".