Actually there's a couple......

Super Smash Bros. Brawl
When it's just me and the cpus, Sometimes I get tossed like a rag-doll due to all of them coming at me at once. I'm fighting a donkey kong cpu, and bowser will come and grab me which gives DK the opportunity to punch me off stage and the third be it any character with a push down attack will strike me down to that never ending pit.

F-Zero, omg, I'll be doing fine until a CPU will hit me; I go flying all around the track, bouncing off the rails and I'll never be able to catch up. & just to add insult to injury I'll pick up speed/acceleration only to get hit again until I reach the finish line or explode.

Lol, I just noticed what I wrote is a bit misleading. It's still a work in progress. I got all gold on National B, National A, and International C. I've been stuck on IB-5 for quite some time now. The frustrating part is that I soooooo close to getting the gold and moving on.

A very rage-inducing moment I had recently was the fight #20 in Dead or Alive: Dimensions Tag Team Mode. The enemies have about 10-15x your health and are MUCH stronger than you (1 combo throw or 1 counter will do about 80-90% damage). Needless to say I got destroyed the first 20-30 times I tried it. Then, when I was just about to give up something suddenly clicked anf I downed the first of them without sustaining too much damage. I then proceeded to bring the other one down to about 1% HP, I literally only needed one more hit. As I tried to counter his attack my CPU ally decided to tag in and got caught in the combo -> dead
During the entering animation the CPU opponent launched his second combo and got me without a chance to counter -> dead

At this point I literally threw my 3DS against the wall, thankfully it didn't receive any lasting damage besides some scratches on the case (it is a Nintendo product afterall :D)

SSBM-Giga bowser event match. I used Jigglypuff's rest. So hard.

Wind Waker-Triforce Quest

Okami-That one bloom dance that Mr.Orange does and you have to help him. Got stuck for an hour and a half on that.

Halo 1-Libarry level on Legendary

I know a friend that has all gold on gt5 licenses using just controller. He is a perfectionist when it comes to getting gold on license tests.

That one mission in Jak II

Playing Yoshis Story.

- Using jets in Battlefield 3.
- Any Call of Duty game on Veteran (G-G-G-G-G-GRENADE).
- Failing the end of a mission in Grand Theft Auto.

Losing at the final boss and being reset to 6-1.  You feel hope die in that moment.

That fuckin' "Chase Calita" from the broken mess that was Driv3r. Seriously, that mission is beyond salvation. You have everything against you, you don't even start the chase properly (You need to turn 180º degrees with the car) and if Calita crashes, nothing happens (She goes on escaping), however, if you do crash, you lose.

THAT FUCKING MISSION.