Wind Waker HD.
I'd loose face if I'd pick anything else besides a Zelda game, whatever Zelda game.
That said, Yoshi's Yarn or whatever is also a game I'm likely going to pick up whenever that will be released. Not much of a Pikmin fan, even though I like the NintendoLand mini-game. X looks good, but not having played Xenoblade, I don't know what to expect. This also goes for Monster Hunter.
LEGO City and, yes, the New Super Luigi DLC look pretty good too. Other games I'm very interested in are Need for Speed Most Wanted and Watch_Dogs, but those are third party. The latter wil be day one though, and if I buy NfS, it'll create the wierd situation where I have more third than first party games on a Nintendo system. That hasn't happened since N64 at least!
EDIT: Lol at 0 votes for Rayman. Outrages at the delay, and then no-one is anticipating it anyway .