The Last Guardian
Last of Us
Xenoblade

GTA V
The Last of Us
FF X HD remake
MGS HD remake
Catherine
The Last Guardian if it releases.

Not real bad, but I'll keep an eye on FFXIII-2 and Silent Hill: Downpour.
And not from 2012, but I yet have to get AC:R

2012 looks much weaker than 2011 and there's not many games I'm very hyped for.

Lost Guardian is the game I'm craving the most by far.

Bioshcok Infinite looks good.

The sequels to Diablo, Risen, Aliens, Max Payne and Alan Wake look okay.

Mass Effect 3
Bioshock Infinite
Silent Hill Downpour (hoping I find it better than Homecoming, fingers crossed!)
Twisted Metal

I´d like to say The Last Guardian, but for now I´m trying to pretend this game doesn´t even exist.

I´m not sure what to think about Asura´s Wrath... yeah the vids are awesome, but I´ll hold judgement till I play a demo or something.

And as a big Ninja Gaiden fan, I´d love to say 'Ninja Gaiden 3', but I´ve got a bad feeling about it.

The Last Story and Bioshock Infinite are by far the ones I want the most. Tales of Graces is finally coming but the long wait has killed all hype I ever had for that title, but perhaps my interest will return.
I don't have a 3DS yet (still preparing my "How to get a 3DS" plan) but Luigi's Mansion 2, Resident Evil and Kid Icarus looks very promising.
I sort of want Pandora's Tower and Fortune Street but neither of them is a must-get.
I really want a WiiU (unless it costs a small fortune or haz no gamez) and Ninja Gaiden 3 looks cool (I've never played a 3D NG game before).

Catherine is already out, and incredibly addicting.

For my list I also want to add Pandora's Tower. Every time I pass up a new IP published by Nintendo, I regret it. There are so many games I at first ignored, but later returned to and love (Pikmin, Eternal Darkness, Baten Kaitos, Conker, Pokemon, etc). I'm hoping it's also a stellar title.

1. Ninja Gaiden III.
2. Hitman: Absolution.
3. Erm............ those are by far my biggest 2, Max Payne 3 perhaps in 3rd place.

Sly 4: Thieves in Time
Mass Effect 3
Prey 2
Tomb Raider
The Last of Us
The Last Guardian
Bioshock Infinite
Journey
Max Payne 3
Grand Theft Auto V

The Last of Us

- Grand Theft Auto 5 (highly likely)
- Call of Duty 9 (as certain as death and taxes)
- Ghost Recon Future Soldier (Set for March)
- Rainbow Six Patriots (unlikely, probably 2013)
- Fallout 4 (more likely 2013, or next gen launch game)
- Respawn Entertainment game (The original creators of Infinity Ward who were fired/quit, there's no news on their current project though but they signed with EA so they're probably hard at work)
- Agent (who the hell knows when this'll come out)
- Gran Turismo 6 (more likely 2013, or just a PS4 launch title)

My two most wanted games right now (any time frame) are Fallout 4 and GTAV.