Never heard of them, plus it's IGN's list

1 - Bowser (Mario series) - 26HP

3 - Smithy (Super Mario RPG) - 32HP 

5 - Donkey Kong (Donkey Kong) - 40HP

8 - Dark Samus/Sa-X (Metroid series) - 25HP

9 - Mother Brain (Metroid series) - 40HP

10 - Ganon / Ganondorf (Zelda series) - 54HP 

11 - Shadow Link/Dark Link (Zelda series) - 36HP

12 - Giygas (Earthbound) - 41HP 

13 - Pokey Minch (Mother Series) - 42HP

14 - King Hippo (Punch-Out!!) - 40HP

15 - Mike Tyson (Mike Tyson's Punch-Out!!) - 25HP 

17 - Officer Tenpenny (Grand Theft Auto: San Andreas) - 37HP

18- Psycho Mantis (Metal Gear Solid series) - 41HP

19 - Sniper Wolf (Metal Gear Solid series) - 29HP

20 - Liquid Snake (Metal Gear Solid series) – 3HP

21 - Big Boss (Metal Gear Solid series) - 43HP

22 - Revolver Ocelot (Metal Gear Solid series) - 49HP

23 - Kefka (Final Fantasy VI) - 59HP

24 - Sephiroth (Final Fantasy VII) – 37HP

25 - Seifer (Final Fantasy VIII) - 37HP

26 - Ultros (Final Fantasy VI) - 33HP

27 - Shang Tsung (Mortal Kombat series) - 40HP

28 - Sub Zero (Mortal Kombat series) - 32HP

29 - Goro (Mortal Kombat series) - 41HP

30 - Akuma (Street Fighter series) - 45HP

32 - Sander Cohen (BioShock) - 20HP

33 - Frank Fontaine (BioShock) - 38HP

34 - Andrew Ryan (BioShock) - 49HP

36 - Ares (God of War) - 40HP

38 - Cronos (God of War III) - 16HP

39 - Magus (Chrono Trigger) - 45HP

40 - Lavos (Chrono Trigger) – 56HP

41 - Prophet of Truth (Halo Series) - 40HP

42 - Covenant (Halo series) - 41HP

43 - Flood (Halo series) - 40HP

44 - Saren (Mass Effect) - 54HP

45 - Geth (Mass Effect series) - 40HP

46 - Harbinger (Mass Effect 2) - 40HP

47 - Combine Soldiers (Half-Life series) - 40HP

48 - Dr. Breen (Half-Life 2) - 40HP

49 - GlaDOS (Portal Series) - 48HP

50 - Albert Wesker (Resident Evil series) - 53HP

51 - Nemesis (Resident Evil 3) - 50HP

53 - Zombies (Many games) - 40HP

54 - Darth Vader (Star Wars series) - 32HP

55 - Darth Malak (Star Wars: Knights of the Old Republic) – 46HP

57 - Arthas (Warcraft III) - 33HP

58 - Kerrigan (StarCraft) - 45HP

59 - Psy-Crow (Earthworm Jim) - 40HP

60 - Bob the Killer Goldfish (Earthworm Jim) - 40HP

62 - Dr. Wily (Mega Man series) - 41HP

63 - Master-D (Bionic Commando) - 40HP

64 - Red Falcon (Contra) - 40HP

66 - Dark Falz (Phantasy Star series) – 37HP

67 - Captain Onishima (Jet Set Radio) - 40HP

68 - Captain Qwark (Ratchet & Clank series) - 40HP

69 - Dr. Nefarious (Ratchet & Clank) - 36HP

70 - Dormin (Shadow of the Colossus) - 41HP

72 - Dagoth Ur (Elder Scrolls III: Morrowind) - 40HP

73 - Jafar/Vizier (Prince of Persia) - 40HP

74 - Gruntilda (Banjo-Kazooie series) - 40HP

75 - Dracula (Castlevania series) - 47HP

76 - Joker (Batman series) - 42HP

77 - John Henry Eden (Fallout 3) - 41HP

78 - Space Invaders Aliens (Space Invaders) - 16HP

79 - Great Mighty Poo (Conker's Bad Fur Day) - 40HP

81 - Cyberdemon (Doom series) - 40HP

82 - Jacqueline Natla (Tomb Raider series) - 40HP

83 - Predator (Aliens vs. Predator) - 40HP

84 - Calypso (Twisted Metal series) - 12HP

85 - Diablo (Diablo series) - 40HP

86 - Alma (F.E.A.R.) - 41HP

87 - Kane (Command & Conquer series) - 42HP

88 - SHODAN (System Shock) - 40HP

89 - Kain (Legacy of Kain series) - 40HP

90 - Sinistar (Sinistar) - 40HP

91 - Mecha-Hitler (Wolfenstein 3D) - 37HP

93 - Death Adder (Golden Axe) - 28HP

94 - Singe (Dragon's Lair) - 40HP

95 - Coily (QBert) - 36HP

96 - Adrian Ripburger (Full Throttle) - 40HP

97 - Purple Tentacle (Day of the Tentacle) - 36HP

97 - Bydo (R-Type) - 36HP

97- Evil Otto (Berzerk) - 40HP

97- LeChuck (Monkey Island) - 43HP

Current Leader:

Kefka (Final Fantasy VI) - 59HP

Death Row:

Liquid Snake (Metal Gear Solid series) – 3HP

Eliminated:

86. King K. Rool (Donkey Kong Country Series)

87. Tank (Left 4 Dead series)

88. Lance Vance (Grand Theft Auto: Vice City)

89. Carmen Sandiego (Where in the World is Carmen Sandiego?)

90. M. Bison (Street Fighter series)

91. Kessler (Infamous)

92. Dr. Robotnik (Sonic the Hedgehog series)

93. Pac-Man Ghosts (Pac-Man)

94. Gary Oak (Pokémon series)

95. Origami Killer (Heavy Rain)

96. Lich King (World of Warcraft)

97.  Wario (Mario series)

98.  Zeus (God of War series)

99.  Team Rocket (Pokémon series)

100.  Sofia Lamb (BioShock 2)

+big boss
- liquid snake (DEAD)

+ Saren

- Mike Tyson

Don't know several of these characters and the ones I do know I don't really want to vote down...

+ Andrew Ryan
- Evil Otto (I guess)

+Kefka
- Sephiroth

+ Lavos
- Dark Samus

+ Saren
- Sephiroth

Zoran is the villian in Uncharted 2. Harry Flynn is..... kind of a bad guy too, but he isn't the main villian

+ Ganon
- Evil Otto