Uncharted 2
MAG
Infamous 2

In no particular order:

Oblivion
Call of Duty 4
Uncharted 2

1) Uncharted 2
2) Super Mario Galaxy 2
3) Super Smash Bros. Brawl

(This will no doubt change by the end of the year)

Really tough call this one. Depends if you count Half-Life 2 as this gen or previous gen.

If it counts then Half-Life 2 + Episodes 1 & 2 first. Else:

Mass Effect 2
Elder Scrolls IV: Oblivion
Uncharted 2

The World Ends with You
Chrono Trigger (DS, was the first time I'd ever played it, anyway)
Enslaved: Odyssey to the West

1. Bioshock
2. Tie: Mario Kart DS / Metroid Prime Trilogy
3. Uncharted 2

This is though...

1. Super Smash Bros. Brawl
2. Uncharted 2
3. Super Mario Galaxy 2 or Donkey Kong Country Returns.

Damn this is hard!
Ratchet and Clank Future
Resistance
Metal Gear Solid Peace Walker

If i could i'd add both Uncharteds' :(

1. Demon's Souls
2. Mass Effect 2
3. Super Mario Galaxy 2

-Honorable Mentions-

4. Super Smash Bros Brawl
5. LittleBigPlanet 2
6. Metal Gear Solid 4

though what?