Infamous 2 for me! I wanted to include more games (Motorstorm 3, Yakuza 4, Twisted Metal, SOCOM 4, etc.) but SONY's output of quality is too much for this poll to handle. I thought those would be the Top 6 that most people would agree on. I intentionally left out unannounced games (Uncharted 3, Resistance 3, etc.) because they would make it harder to pick 6 games. 

Yakuza 4

Resistance 3...but since that still isn't announced I'll go for FF Versus XIII

FINAL FANTASY VERSUS XIII

Resistance 3, Killzone 3, and LBP 2.

Final Fantasy XIII Versus(if it remains excluisive) EDIT: though it still would be my most wanted)

the rest:(from wanted to least wanted)

Infamous 2

Killzone 3

LittleBigPlantet 2

The Last Guardian

Gran Turismo 5(won't probably get this)

edit: Final Fantasy Versus XIII if it remains exclusive.

Ift not. Final Fantasy Versus XIII is my most anticipated. tied with by deus ex 3  (not ps3 exclusive)

The Last Guardian without question. I still pop in Shadow of the Colossus every couple of months for some play time. The atmosphere is just so palpable and I can't wait to see how much more they can do with it with the PS3s capabilities.

FF Versus XIII ( exclusive or not ) > The last guardian >>>>>>>>>>>>>>>>>>>>>  LBP2 >>>>>>infamous2

anything that's not racing or FPS 

Gran Turismoooooooooooo 5!!!!!!!, (screamed in the same way the Nintendo 64 kid screams christmas morning)