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Salnax said:

Dr. Mario. The last entry in the series was that failed mobile game that shut down after 2 years, and the one before that was on the 3DS over 10 years ago. Unless the games sell that terribly, I'm pretty sure we'll get a new entry sooner or later.

Dr. Mario is low-budget and has had many installments. I too feel it is inevitable to make a comeback. 

Dr. Mario - 1990

64 - 2001

Online RX - 2008

Express - 2008

Dr. Luigi - 2014

Miracle Cure - 2015

World - 2019

The first Dr. Mario got ports and stuff and took a long time to get a sequel. World could be followed up on Switch 2 in 2026-2031 with a new title. 



Lifetime Sales Predictions 

Switch: 161 million (was 73 million, then 96 million, then 113 million, then 125 million, then 144 million, then 151 million, then 156 million)

PS5: 122 million (was 105 million, then 115 million) Xbox Series X/S: 38 million (was 60 million, then 67 million, then 57 million. then 48 million. then 40 million)

Switch 2: 120 million (was 116 million)

PS4: 120 mil (was 100 then 130 million, then 122 million) Xbox One: 51 mil (was 50 then 55 mil)

3DS: 75.5 mil (was 73, then 77 million)

"Let go your earthly tether, enter the void, empty and become wind." - Guru Laghima