I know it's not going to happen, but please be Dead Rising, please be Dead Rising, please be Dead Rising, please be Dead Rising, please be Dead Rising...
Chainsaws+Wiimote controls=hours of fun.
And unfortunately, I also doubt it'll be Resident Evil 5. After the beauty that was 4, I can't think of anything a port of 5 would possess that would make it a "surprising take" (beyond being on the Wii in the first place). But I'll be happy to be proven wrong!