Let's take a look at each of the DS's 18 and see whether they can be replaced.
New Super Mario Bros - YES by NSMB2
Nintendogs - NOT Sucessfully Replicated
Mario Kart DS - YES by MK7
Brain Age - NOT by Brain Age 3
Pokemon G4 - YES by G6
Brain Age 2 - NO Replacement
Pokemon G5 - UNKNOWN
Animal Crossing: Wild World - YES by New Leaf
Pokemon G2 Remakes - YES by G3 Remakes
Super Mario 64 DS - YES by 3D Land
Mario Party DS - MAYBE by Party 3D (coming out soon)
Pokemon Platinum - PROBABLY by Pokemon Z
Pokemon G5 2 - Unknown
Big Brain Academy - NOT by anything
Dragon Quest 9 - MAYBE by Dragon Quest 11
Cooking Mama - NO
Professor Layton - NO
Mario & Sonic - NO
In short, we need at least eight new 5-million sellers to reach DS levels. So what are the likely cnadidates?
The following nominees are not all confirmed, and have a percentage next to them based off of how likely I think they are to reach 5 million.
Pokemon G3 Remakes (90%)
Pokemon Z (80%)
Dragon Quest 11 (80%)
Monster Hunter 4 (70%)
Luigi's Mansion: DM (65%)
Mario Party 3D (60%)
Ocarina of Time 3D (50%)
Link to the Past 2 (40%)
Super Smash Bros 4 (30%)
Even if the 3DS kills the Vita and becomes the only major handheld on the market, the only candaidate it's stolen is Monster Hunter.
If Nintendo wants to make more big sellers, they need to have:
*Super Mario 3D Land 2 (Probably will sell 50 or 60% of the original)
*Cheaper rereleases of certain games, ala Nintendo selects
*Pokemon Generation 7 as well as 6, including its own "Yellow" version
*An original Donkey Kong platformer
*A major Mii-themed game
*Some major Pokemon spinoff, ala Stadium for the N64, Mystery Dungeon for the GBA/DS, Pinballl for the GBC, etc
*Entirely new franchises







