How would multiplayer work with Wii U?

[theRepublic]

I've seen a lot of asymmetrical gameplay concepts so far. It actually has me very excited because on of my favorite multiplayer experiences was like this. It was a game called Pac-Man Vs. Three players played as the ghosts. They used the TV screen and could only see a small part of the maze. The fourth player played as Pac-Man using a GBA connected to the Gamecube. It was a blast, but almost no one played it.

I suspect that there will also be a lot of games that only use the Wii remotes and nunchucks for multiplayer too.