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I can see a 2nd Mario Kart game either on DS or Wii. Only because I believe they will last longer than the previous Nintendo systems. It would most likely be on the Wii though since it would probably sell more, have better online etc...

It's a maybe though, I know previous gens only had 1 mario kart per system, but we said that for 3D Mario games. Anything is possible, especially if Nintendo wants a lot of money.

2001 - GBA
2003 - GC
2005 - DS
2008 - Wii
2011 - Wii?

If not 2011, I definitely think one will come out in 2012. and maybe Nintendo will still have their current systems by then. Who knows!? It would be nice though.